cancer
edyong | April 11, 2008For comic book characters, big doses of radiation are a surefire way of acquiring awesome superpowers, but in real life, the results aren't quite as glamorous. A victim of acute radiation poisoning can look forward to hair loss, bleeding, the destruction of their white blood cells and bone marrow, and severe damage to their spleen, stomach and intestines.
Radiation doesn't kill cells directly, but it can cause so much damage that they commit suicide, by enacting a failsafe program called apoptosis. Now, Lyudmila Burdelya and colleagues from Roswell Park Cancer Institute have found a way to…
oracknows | April 7, 2008...or so says #1 Dinosaur, who was buried under a blizzard of radiology reports.
I tend to agree up to a point, but the only problem from my perspective is this: Until recently, it was not at all uncommon for me to get seemingly millions of copies of every radiology report for mammography, ultrasound, and core needle biopsies on my patients. There's a preliminary report, a final report, an amended report, a report with the pathology report added, a report with the pathology report and the estrogen/progesterone receptor status added, and then multiple copies of the final report. We ended up…
oracknows | April 5, 2008...at the Cancer Research Blog Carnival #8, hosted over at The Skeptical Alchemist.
Just the thing to while away a Saturday afternoon!
terrasig | April 4, 2008Actinomycin D was the first antitumor antibiotic isolated from Streptomyces parvallus cultures by the lab of 1952 Nobel laureate, Dr Selman Waksman, at Rutgers University. However, it took a young Chinese physician and the confidence in her by a future US Surgeon General for this natural product drug to positively impact the lives of children with cancer.
An unusually engaging Boston Globe obituary by Gloria Negri caught my attention this week that announced the death of pediatric oncology pioneer, Charlotte Tan (Hsu), MD, of pneumonia on 1 April in Brookline, MA. Dr Tan's 1959 paper in…
oracknows | March 31, 2008I have to admit that this one fell off the radar, even for me. I hate to admit it, but it's true.
I'm talking about the Cancer Research Blog Carnival, which is being hosted by the Skeptical Alchemist this Friday.
So, those of you inclined to write about cancer and cancer research, help a blogger out and submit your work to the Skeptical Alchemist before Friday and then come back to check out the carnival then.
oracknows | March 25, 2008The annoying death crud that has gripped me continues apace. Fortunately, I happen to have a rather interesting guest blog post that I've had lying around a while, and now seems like the perfect time to use it. It comes from Dr. Arnon Krongrad, an expert in prostate cancer and minimally invasive surgery. I'm publishing it because he has a rather interesting observation about the use of supplements and how it may contribute to the development of aggressive prostate cancer. Here is Dr. Krongrad's contribution:
What would you pay to have erections? Would you pay with your life? A report from…
oracknows | March 21, 2008Sometimes a topic demands to be included in my little Friday bit of hubris and tweaking. Usually when that happens, it's obvious because somehow the topic is synergistic with what's been going on during the preceding week on the ol' blog, in the same way that herbalists claim that all the various compounds and contaminants somehow produce a synergistic therapeutic effect. Wait a minute. That's not such a good example, mainly because woo-meisters usually make this claim without much in the way of evidence, and the examples of true synergism between components of an herbal remedy are few and…
apalazzo | March 21, 2008Last time I told you about how the view of cancer switched from the perspective of metabolism to oncogenes. Today we'll see how recent developments have placed the spotlight back on metabolic pathways.
I'll begin this tale with a quote from a review written by Andrew M Arshama and Thomas P Neufeld:
The TOR (target of rapamycin) signaling pathway has been the subject of a 30-year-long reverse engineering project, beginning in the 1970s when the macrocyclic lactone antifungal compound rapamycin was purified from soil bacteria found on the Pacific island of Rapa Nui, famous for its moai (giant…
terrasig | March 12, 2008[Welcome mental_floss blog and Daily Kos readers. After you read about this outstanding young woman, you can learn more about me, my life story, and this blog here.]
If you read elsewhere at ScienceBlogs.com, you'll know that several bloggers have been discussing race and gender issues in the scientific and medical research communities as well as the challenges facing young scientists who pursue academic research careers. So, I was overjoyed this morning to see this glowing face on Shivani Sud, a local young woman of Indian heritage who took first prize in the Intel Science Talent Search (…
oracknows | March 12, 2008After a bit of ranting earlier this week, I thought now would be a good time to cool it down a bit, if only for a moment. There's plenty more out there to rant about, but I'm intentionally ignoring it, if only for a day (or even half a day). If there's one thing I've learned about blogging in the three years I've indulged in this little habit of mine, it's that a blogger has to mix things up. Too many rants in a row, and even I start to get bored. And if I'm bored you're almost certainly bored.
We wouldn't want that, now, would we?
So it was with great interest that I came across, albeit…
oracknows | March 6, 2008Yesterday was a rather long day, starting with a long commute in the morning, followed by a long day in the office mainly doing grant paperwork, and capped off by getting home late. Even so, I couldn't ignore this particular story for two reasons. First, it's about so-called "alternative" medicine. Second, it's about Steve Jobs, co-founder of Apple Computer and the creative, if at times arrogant and abusive, creative genius behind Apple's recovery from the brink of bankruptcy 11 years ago to its current situation, where its computers are cool; its operating system rocks; and it rules over the…
revere | February 27, 2008Chromium is OK when it's on your car bumper but not so OK when it's in your workplace air or your drinking water. That's because chromium, in some of its forms, causes cancer. In fact it is a remarkably good carcinogen. A few years, ago both epidemiological studies and risk estimates done by the US Environmental Protection Agency (EPA) suggested the lifetime risk of dying of lung cancer for workers exposed at the then workplace limits as about 25%. This is higher than for heavy cigarette smokers. The US Occupational Safety and Health Administration (OSHA) lowered the workplace standard by a…
oracknows | February 26, 2008In a way, I have to hand it to Mike Adams.
As you may recall, Mike Adams is the man behind what is arguably one of the top two or three woo-filled sites on the Internet, NaturalNews.com (formerly known as NewsTarget.com). I'm hard-pressed to come up with an example of someone who can deliver delusional paranoid conspiracy-mongering against the FDA, CDC, and big pharma, antivaccination lunacy, overblown claims about cancer, and (in my considered medical opinion, of course), dangerous cancer quackery, all in one tidy, ranting package. Sometimes the stuff Adams writes is so over-the-top that I…
oracknows | February 14, 2008It figures again.
I go a few days without Internet access again, and not only does Generation Rescue take out a full page antivaccination ad full of stupidity in USA Today, which I couldn't resist opening both barrels on earlier, but a study's lead senior author is someone I know (albeit not well) about three topics I'm very interested in: breast cancer, health information on the Internet, and so-called "complementary and alternative" medicine. Not surprisingly, in my absence blog stalwarts Abel Pharmboy and Steve Novella already beat me to it in fine form. You might ask if that would in any…
terrasig | February 14, 2008It seems that everyone in the sci/med blogosphere is offering Valentine's posts reflecting their areas of professional interest. So, here's mine:
Your humble Pharmboy came of age with glam, punk, and New Wave music but thanks to PharmMom, RN, and her then-college-aged ER co-workers, I have a soft spot for 70s soft-rocking singer-songwriters. Yes, Jim Croce, John Denver, James Taylor, and Dan Fogelberg.
So it was with great interest and nostalgia that I opened this e-mail a few days ago from the Prostate Cancer Foundation:
Dan Fogelberg, the singer and songwriter whose hits "Leader of the…
terrasig | February 12, 2008There are responsible ways to present medical information and irresponsible ways. I will say at the outset that I have no ethical issues with discussing complementary and alternative medicine (CAM) with cancer patients, as long as the information presented is based in fact.
So it was no surprise to me and actually quite alarming to read a recent report suggesting that while only 1 in 20 breast cancer websites offer incorrect information, CAM-focused websites were 15 times more likely to contain inaccurate or incorrect information. The study to which I refer will appear in the 15 March issue…
oracknows | February 7, 2008I was perusing my newsfeeds last night looking for topics for Your Friday Dose of Woo this week when I came across what, initially at least, I considered to be primo material for my weekly bit of fun at the expense of the more far out excursions into woo. Then I thought about it some more. Early in the history of YFDoW, I admit that I did a couple of misfires. Perhaps the most notorious misfire was when I decided to take on the German New Medicine. Certainly the woo was there and it was good, but I quickly regretted taking such a lighthearted approach to this topic because it quickly became…
terrasig | January 28, 2008If you read nothing else: Men with prostate cancer should avoid any dietary supplement containing testosterone (or anything that sounds like it) or that offers claims of increased virility, sexual performance, or increased muscle mass.
Consumption of a herbal/hormone dietary supplement has been linked to two cases of aggressive prostate cancer as reported in a paper in the 15 January issue of Clinical Cancer Research (abstract free; full paper paywalled) . The observations and follow-up studies were conducted by urologists at the University of Texas Southwestern Medical School and Baylor…
oracknows | January 22, 2008Let's face it. These days, research papers in the peer-reviewed biomedical scientific literature are becoming more and more complex and difficult to understand. For many journals, it seems, if you don't have at least seven meaty, dense, multipanel figures (preferably some of which with flashy color confocal microscopy), you don't have a prayer of getting published. Along with the requisite multiple figures, it seems, the prose has become more impenetrable even over the 23 years or so since I graduated from college and embarked upon my current career. Scientific papers in the old days (say, as…
revere | January 18, 2008Another story about a "new" screening test, this one for prostate cancer, the most common cancer in the US. This one looks for a particular combination of variations in five genes. If a man has all five and a family history of prostate cancer then his risk of is increased by a factor of nine. The researchers who have devised the test have also patented it and plan to sell it for $300 bucks a pop. I, for one, am not buying it (literally or figuratively). First some of the details as given by a press report:
Almost half of prostate cancer patients carry five genetic variations and a family…