cancer
oracknows | October 11, 2007I should have guessed.
Leave it to uber-crank (a. k. a. One Crank To Rule Them All) Mike Adams, the "intellect" behind what is perhaps the crankiest website known to humankind (at least when it comes to medicine), NewsTarget.com, to try to slime Breast Cancer Awareness Month. As fellow ScienceBlogger Mark points out, in his "report" Breast Cancer Deception, Adams accomplishes this by characterizing Breast Cancer Awareness month as nothing more than part of a conspiracy by the "male-dominated" cancer industry to keep women down.
I have to admit, in the realm of sheer wingnuttery, I've seldom…
oracknows | October 10, 2007Here we are, a third of the way into Breast Cancer Awareness Month, and I haven't yet written a piece about breast cancer. Given that it's my primary surgical specialty, perhaps some readers were wondering why not. Truth be told, I've always been a bit ambivalent about Breast Cancer Awareness month. Perhaps it has something to do with the fact that my job makes every month Breast Cancer Awareness month. Or maybe it has something to do with the crassness of some of the promotions designed to attract donations, well-meaning though such campaigns undoubtedly are. From my perspective, any month…
oracknows | October 7, 2007I've had this story sent to me by a few readers over the weekend, and I think it's worth a brief comment.
I'm basically a child of the 1970s. Although I didn't watch it much, if ever, I remember Charlie's Angels when I was in junior high and high school. Like any adolescent who came of age in the late 1970s, I remember the famous and hot-selling poster of Farrah Fawcett, which graced the bedroom of more than one of my friends, although I never actually owned a copy. A while back, I heard that Fawcett had been successfully treated for anal cancer. Now, I hear from my readers that her anal…
terrasig | October 4, 2007...but a chemically-altered analog derived from feverfew appears to have anticancer activity against leukemia stem cells. Researchers at the University of Rochester reported this week in the journal, Blood, that dimethylaminoparthenolide (DMAPT) has selective action against acute myeloid leukemia (AML).
It'll be a couple days before I can get to reading the original paper. However, do not let anyone tell you that feverfew can treat cancer. From the press release, it appears that the major compound in feverfew, called parthenolide, was chemically modified to create DMAPT, thereby…
terrasig | October 4, 2007Although the dichloroacetate (DCA) horse has been beaten beyond recognition, PharmCanuck sends some interesting news from north of the border about how University of Alberta researchers have generated funds to support their clinical trial of this unpatented compound.
Our correspondent writes:
I was a stunned this morning when I read an online article on the CBC website (http://www.cbc.ca/health/story/2007/10/04/fundraising-dca.html) revealing the source of the trial funding. Amazingly, almost 1/3 ($250K) of the $800K raised has come from the efforts of the small town of Peace River, Alberta…
oracknows | October 4, 2007I've made no secret how much contempt I have for Kevin Trudeau, whom I have likened to David Irving, at least with respect to his respect for the truth. He has made many, many millions of dollars selling books with titles like Natural Cures "They" Don't Want You to Know About and its followups, in which he claims that there are "natural" cures for all sorts of diseases that the usual cabal of big pharma, the AMA, and the FDA are keeping away from you--yes, you!--in order to protect the profits of big pharma and the hegemony of us "conventional" physicians. Obviously, Trudeau is a total hack…
oracknows | October 1, 2007I've written a lot about dichloroacetate, a.k.a. DCA (my last post here, along with links to my previous posts), the small molecule drug that burst onto the scene after Evangelos Michelakis of the University of Alberta published a paper in Cancer Cell in January describing strong anti-tumor activity in preclinical models (in this case, a rat model) of several different cancers.
Scientifically, DCA is interesting because, unlike many previous chemotherapeutic agents, it targets the energetics of the cell, specifically an alteration in cancer cells known as the Warburg effect. This is an idea…
terrasig | September 30, 2007Do you remember dicholoroacetate (DCA)?
In a letter dated 24 September (PDF here), Dr Evangelos Michelakis of the University of Alberta announced that his group had received approval from Health Canada and U of A's institutional review board to begin a Phase II clinical trial of dichloroacetate (DCA). The trial will enroll 50 patients with astrocytomas or glioblastomas, two classes of malignant brain tumors, who have either been newly diagnosed or have not responded to previous therapies. The purpose of a Phase II trial is to provide an initial assessment of drug efficacy in a small…
oracknows | September 28, 2007Because if you're going to make health claims and claim to treat patients, you should be held just as accountable as any physician:
A Carson City "anti-aging" doctor has pleaded guilty to malpractice for failing to diagnose an elderly patient with the cancer that ultimately killed him.
It is Dr. Frank Anthony Shallenberger's second discipline by the Nevada Board of Medical Examiners in 12 years.
Shallenberger's plea last week regarding patient David Horton's care came on the heels of the board's dismissal of another family's complaint related to Shallenberger's treatment of their sister,…
oracknows | September 23, 2007Believe it or not, this post is related, albeit somewhat tangentially, to my area of expertise, breast cancer. It's also related to one of my great loves in life, namely loud, obnoxious rock and roll. Unfortunately, it involves bad art and an album cover so puzzling that, even when considering the source, I have a hard time figuring out just what the heck they were thinking when they put this album cover together.
I'm talking about, believe it or not, the cover of the new Ted Nugent album Love Grenade.
I know, I know, it's not as if one expects the cover of a Ted Nugent album to make sense.…
terrasig | September 19, 2007A few days ago, I posted about a 1 September Cancer Research paper showing that a muscadine grape skin extract (MSKE) lacking resveratrol had activity in killing prostate cancer cells. I've finally had a chance to look at the paper. The study was very well-done by Dr Jeffrey Green's group at the US National Cancer Institute with colleagues at Georgia, Texas, USDA, and George Washington University. The studies showed that the grape skin extract (at 10-20 μg/mL) had cytotoxic activity against progressively tumorigenic prostate cell lines but had no effect on normal prostatic epithelial cells…
oracknows | September 19, 2007Last week, upon arriving back at my office after a day in clinic, I noticed an odd box sitting in my "in" box. I didn't recall having ordered anything recently, and my first thought was that an order for the laboratory had somehow been delivered to my office instead of my lab by mistake. It's uncommon, but it occasionally happens. Curiosity piqued, I picked up the box. It was small, only a few inches high, and lighter than I had expected. I couldn't hear any swishing that might indicated a powdered reagent in a bottle in the box. Moreover, upon closer inspection, I noticed that the box had no…
oracknows | September 18, 2007I'm rather amused.
No, I'm very amused.
Yesterday, as you may recall, I discussed a seemingly alarming e-mail that's going around about a 17-year-old boy with melanoma whom the State of California had allegedly removed from the custody of his mother because she and he had wanted to use "advanced natural medicine" to treat his melanoma, rather than surgery and chemotherapy. I pointed out a number of questionable elements in the story that made me very suspicious of its accuracy, not the least of which is the fact that the mainstay of melanoma treatment is surgery plus biological therapy, not…
oracknows | September 18, 2007My recent update of my ongoing discussion of the Abraham Cherrix case reminded me that there's a bit of alarming e-mail being sent out and forwarded far and wide. If you read it, at first glance, you will think it sounds utterly horrifying, the Abraham Cherrix and Katie Wernecke cases all rolled up into one and then placed on steroids to the point that even a maven of evidence-based medicine would have to take pause--if the story were true.
The source of the e-mail seems to be the Natural Solutions Foundation/Health Freedom USA, given all the "donate" buttons in the webpage to which I tracked…
oracknows | September 17, 2007While I'm flogging blog carnivals, here's another one that's right up my alley that seemingly came into existence without my having been aware of it: the Cancer Research Blog Carnival.
The first edition of the carnival at Bayblab has a lot of good stuff. The next edition will be at nosugrefneb.com on October 5. I might have to submit a piece.
oracknows | September 17, 2007
It would appear that there's finally some good news in the strange and sad case of Starchild Abraham Cherrix. The AP reports that he and his doctor are reporting that his lymphoma is in remission again:
FLOYD, Va. -- A 17-year-old who won a court battle against state officials who tried to force him to undergo chemotherapy for his lymphatic cancer is in remission following radiation treatments over the past year, the teen and his doctor said.
Starchild Abraham Cherrix's case spurred debate on whether the government should get involved in family medical decisions. It also led to a state law…
terrasig | September 16, 2007Leukemia Drug Adulteration
Chinese generic versions of the anticancer drugs, methotrexate and cytarabine hydrochloride, have been reported to be contaminated with an undisclosed substance according to several wire reports this morning.
Several children in a Shanghai hospital were reported to suffer leg pain and difficulty walking after being injected with methotrexate. A common drug used in many chemotherapy regimens for leukemia, methotrexate is not normally associated with these side effects.
The Xinhua news agency reported that the drugs had been traced to one manufacturer, Shanghai…
oracknows | September 14, 2007
Earlier this week, I deconstructed a truly inane article on Mike Adams NewsTarget website espousing dangerous cancer quackery, with claims that herbal concoctions alone could "naturally heal" cancer. Such a claim wouldn't have attracted bringing the hammer of Respectful Insolence⢠down if there had been some actual evidence presented that this healer could do what she claimed she could do. Unfortunately, as is the case with virtually all such claims, there was none, just a complicated regimen involving four or five different herbal brews involving a total of around 40 different plants and…
terrasig | September 14, 2007[Welcome Daily Kos readers and many thanks to DarkSyde for the link - btw, if you're wondering what Terra Sigillata is, click here.]
The other day I fired off a quick post on the absurdity of the Centers for Medicare and Medicaid Services (CMS) is proposing to cut reimbursements for two radioimmunotherapy drugs for lymphoma to less than their cost. The two immunotherapy drugs in question are Bexxar (I-131 tositumomab) and Zevalin (Y-90 ibritumomab) - both drugs target the CD20 protein on the surface of normal and malignant B-lymphocytes, killing the cells by the radioactive emissions of…
terrasig | September 12, 2007Just a quick post about observations I had at a recent prostate cancer meeting conducted by the US Department of Defense's (DOD) Congressionally-Directed Medical Research Program (CDMRP). In the US, DOD is second only to NIH in the amount of funding provided for breast and prostate cancer research.
The meeting was held in Atlanta and spread over three days - a nice small meeting with few overlapping sessions and great opportunities for interaction with speakers and fellow scientists.
Most impressive, however, was the heavy presence of the cancer patient community in the proceedings. The…