Clinical trials
oracknows | April 2, 2014As regular readers know, I was quite happy that Skeptical Inquirer (SI) agreed to publish articles by Bob Blaskiewicz and myself about the highly dubious cancer doctor in Houston known as Stanislaw Burzynski. Indeed, Bob and I have been busily doing our best to promote it, appearing on various podcasts, including Point of Inquiry and, most recently, The Skeptics' Guide to the Universe, where once again we've called on skeptics to help us put pressure on our elected officials to prevent Dr. Burzynski from continuing to take advantage of desperate cancer patients, many with incurable disease,…
oracknows | April 1, 2014Of all the cranks, quacks, antivaccinationists, and pseudoscientists that I've encountered (and applied a bit of not-so-Respectful Insolence to) over the years, there are a few who belong in the top tier—or, if you prefer, the bottom tier. They stick out in my memory for a variety of reasons, either through their sheer crankitude on a variety of subjects (such as Mike Adams), sheer persistence on one subject (such as Jake Crosby or any of the denizens of the antivaccine crank blogs Age of Autism or The Thinking Moms' Revolution), or fame for promoting quackery (Joe Mercola). One of these…
oracknows | March 27, 2014Note: I was busy doing something last night that left me no time to compose any fresh Insolence, which will become apparent by this weekend. In the meantime, however, I'm betting quite a few of you haven't seen this before, and those who have might want to discuss it further in a different environment.
Quackademic medicine.
I love that term, because it succinctly describes the infiltration of pseudoscientific medicine into medical academia. As I've said many times, I wish I had been the one to coin the phrase, but I wasn't. To the best of my ability to determine, I first picked it up from Dr…
oracknows | March 23, 2014As I sat down to write this bit of Insolence, I had at least two ideas for what I thought would be informative, entertaining, and timely posts. I also didn't want to have to write about Stanislaw Burzynski again after having just done so on Friday, having to note that the FDA caved, granting compassionate use exemptions to use antineoplastons (ANPs) to several patients who had been lobbying for just such exemptions. I already described why what the FDA did was horrifically cynical. When I first saw the message rejoicing of the FDA's decision in message on the Prayers for Elisha Facebook page…
oracknows | March 21, 2014
"Just when I thought I was out, they pull me back in."
I know I've used that quote before several times over the 9+ years that I've been blogging. These days, I probably use it most frequently when it comes to the topic of Stanislaw Burzynski. Every time I think that I can give the topic a rest for a while (and, believe me, I do want to give it a rest), something invariably seems to happen to pull me back in. So it was yesterday when i was made aware of a new development so disappointing that I'm still wiping the dirt off my chin from my jaw dropping to the floor. Even more amazing is that…
oracknows | March 20, 2014If there's one thing a budding skeptic quickly learns is that at the core of any good woo almost invariably lurks at least one conspiracy theory. At the risk of flirting a little too close to Godwin territory, this simple fact about pseudoscience, pseudohistory, and other non-evidence-based belief systems was first driven home to me around 15 years ago when I first started becoming interested in Holocaust denial. It didn't take too long for me to discover that at the heart of Holocaust denial are various conspiracy theories. Somehow the Jews, we are told, conspired to exaggerate the number of…
oracknows | March 13, 2014If there's a topic that I don't write about much, it's obstetrics. The reason is that it's not a major area of my interest, and it's not an area where I have as much expertise as I do in, say, cancer or even vaccines. My expertise in cancer comes from my career, of course, and my expertise in vaccines is self-taught through my 9+ years of blogging about it. Ditto my expertise in "complementary and alternative medicine" (CAM), also known as "integrative medicine," about which I know quite a lot now. That's probably why I didn't pay much attention to a study that came out in late January from…
oracknows | March 10, 2014I forgot if I ever mentioned that I have an article out in the current episode of Skeptical Inquirer about Stanislaw Burzynski. I call it a "primer for skeptics," because that's what it is. So, if you subscribe to SI (Skeptical Inquirer, not Sports Illustrated), read. If not, get thee to a newsstand before it's gone. Thus endeth the plug and beginneth the Insolence.
When last I discussed Stanislaw Burzynski, I noted that, among other things, the state of Texas appears far more interested in putting abortion providers out of business than it does in protecting its citizens suffering from…
oracknows | March 6, 2014One of my favorite shows right now is True Detective, an HBO show in which two cops pursue a serial killer over the course of over 16 years. Starring Woody Harrelson and Matthew McConaughey, it's an amazingly creepy show, and McConaughey is amazing at playing his character, Rustin Cohle. I'm sad that the show will be ending this week.
Unfortunately, as much as I like Matthew McConaughey as an actor, he is in part responsible for re-inspiring a movement that has the potential to do profound harm to patients and cancer research. That's because his other big role over the last year has been in…
oracknows | February 26, 2014Rare is the occasion when I disagree significantly with my collaborator Steve Novella, but this is one of those times. It's a measure of how much we agree on most things that, even in this case, I don't completely disagree with him. But, hey, it happens. I'm referring to Steve's post yesterday in which he gushed over the new policy at PLoS (Public Library of Science) regarding articles published in their journals. (Steve rarely gushes.) Here's the policy:
In an effort to increase access to this data, we are now revising our data-sharing policy for all PLOS journals: authors must make all…
oracknows | February 16, 2014The last couple of weeks, I've made allusions to the "Bat Signal" (or, as I called it, the "Cancer Signal," although that's a horrible name and I need to think of a better one). Basically, when Bat Cancer Signal goes up (hey, I like that one better, but do bats get cancer?), it means that a study or story has hit the press that demands my attention. It happened again just last week, when stories started hitting the press hot and heavy about a new study of mammography, stories with titles like Vast Study Casts Doubts on Value of Mammograms and Do Mammograms Save Lives? ‘Hardly,’ a New Study…
oracknows | February 13, 2014I must confess, I had a rather rough time yesterday. Actually, it's been a rough winter, at least as far as my car is concerned. Record amounts of snow and a January much colder than usual have wreaked havoc on the roads around where I live, producing craters that make our roads and freeways look more like the surface of the moon than anything you'd want to go speeding along on in an automobile. So it was that about a month ago on my way to work I couldn't avoid a particularly nasty crater, and immediately after I hit it I knew something was wrong. My tire pressure light went on, and the car…
oracknows | February 11, 2014I don't know if it's a sign that I've arrived as being a bit more influential than just a blogger or just dumb luck when reporters start sending me things, but I'll take it. It's like blog fodder being served to me on the proverbial silver platter. Unfortunately, as a result of receiving a press release, FDA Denies Treatment to Two Terminally Ill Young Women, from two different sources, after yesterday's hilarious (if I do say so myself) bit of fun with a certain woman who fancies herself a "Thinker" when everything she writes shows that she is anything but, I find myself tackling a much more…
oracknows | February 9, 2014There are certain things that can happen that are the equivalent of the Bat Signal to me; that is, if you can swallow the idea of me being in any way like Bruce Wayne. Call them the Cancer Signal, if you will. When I see the Cancer Signal, I know that I have to head down to the Cancer Cave—wait a minute, that doesn't sound right. Scratch that. In any caes, there are certain studies or stories that basically demand my attention and say, "Blog me, Orac! Blog me right now!!!" Either that, or they're studies that capture my readers' attention, leading them to e-mail me or Tweet at me plaintive…
oracknows | February 7, 2014If there's one thing that I write that I don't feel I repeat too much (although some might disagree), it's that, unlike other centers and institutes at the National Institutes of Health (NIH), there is not, and never was, a compelling scientific justification for the National Center for Complementary and Alternative Medicine (NCCAM) to exist as a separate entity. There is nothing that NCCAM does that couldn't be done just as well in other parts of the NIH, with the exception of research into modalities with such low prior plausibility and such fantastical proposed mechanisms of working that…
oracknows | January 30, 2014Believe it or not, I'm about to say the one and only good thing I will say about Stanislaw Burzynski in this post. After all, I was always taught to find the good in my opponents, no matter how vile I find them. Burzynski, for instance, has been peddling a cure for brain cancer (and other cancers) that he claims to have discovered in the blood and urine in the 1970s. Despite there being no convincing evidence of antitumor activity due to these peptides, which he dubbed antineoplastons, he has managed to win battle after battle with the FDA and the Texas Medical Board and to continue to prey…
oracknows | January 22, 2014I realize that I just wrote about infamous cancer doctor Stanislaw Burzynski yesterday. (Note how I refuse to call him an "oncologist," mainly because he isn't one, having never completed an oncology fellowship—or even an internal medicine residency, the usual prerequisite to do an oncology fellowship.) However, there's a bit more that I wanted to touch on before moving on to other topics. What brought this on was a Google Alert that appeared in my in box yesterday relevant to yesterday's post. You might recall that yesterday I mentioned a campaign by the Alliance for Natural Health USA (ANH-…
oracknows | January 20, 2014The year 2013 finished with serious setbacks for Stanislaw Burzynski and his unproven cancer treatment that he dubbed "antineoplastons" (ANPs) way back in the early 1970s. As you might recall, in November, two things happened. First, the FDA released its initial reports on its inspection of the Burzynski Clinic and Burzynski Research Institute (BRI) carried out from January to March 2013. They were damning in the extreme, pointing out the shoddy operating methods of the institutional review board (IRB) used by the BRI to approve and oversee Burzynski's "clinical trials" (and I use the term…
oracknows | January 16, 2014Practitioners of "complementary and alternative medicine" (CAM) have a love-hate relationship with randomized clinical trials (RCTs). Actually, it's mostly hate, but they do crave the validation that only randomized clinical trials can provide within the paradigm of evidence-based medicine (EBM). Yes, I intentionally said EBM, rather than science-based medicine (SBM), because, as I've described so many times before, the two are not the same thing. EBM fetishizes clinical trials, a fixation that I sometimes call "methodolatry," defined by a blog bud of mine from long ago as the "profane…
oracknows | January 15, 2014Here we go again. In the wake of study after study that fails to find activity of various "complementary and alternative medicine" (CAM) beyond that of placebo, the campaign to a "rebrand" CAM as "working" through the "power of placebo" continues apace, in the wake of the successful campaign to "rebrand" various needle-based medical modalities as "acupuncture." Personally, I've argued that in reality this new focus on placebo effects as the "mechanism" through which CAM "works" is in reality more a manifestation of the common fantasy that wishing makes it so. Meanwhile I've argued that this…