Various viruses
tsmith | February 25, 2010Student guest post by Desiré Christensen
Human papillomaviruses (HPVs) are small DNA viruses that infect epithelial cells. There are well over 100 subtypes of HPV. The subtypes that infect cutaneous epithelia are termed beta-HPVs and those that infect the mucosal epithelia are termed alpha-HPVs. Some alpha-HPVs have received attention as strong risk factors for the development of cervical cancer. Less public awareness has been generated over the role of HPVs in the development of other cancers such as vulvar, vaginal, anal, head and neck, and penile cancers. Only recent research has…
tsmith | February 25, 2010Student guest post by Andrew Behan
Type I Diabetes Mellitus (T1DM) is a disease most affecting children (previously named juvenile-onset diabetes). However, adults can still develop this life-threatening illness. Research in the genetic arena has provided evidence this disease is partially due to inheritance, leaving a portion of causality yet to be determined. More specifically, a look at certain viruses which attack the beta cells of the pancreas, the cells responsible for producing insulin, have provided new information regarding etiology of T1DM. Some recent research aimed at…
tsmith | February 23, 2010Student guest post by Dayna Groskreutz
Heart disease is the leading cause of death in adults in the United States. Acute coronary syndrome (ACS) is a term which includes both heart attacks and unstable angina. ACS occurs, in part, due to atherosclerosis, or plaque accumulation leading to narrowing of the artery. Some known risk factors for atherosclerosis and ACS include smoking, family history, high blood pressure, and high cholesterol. Recently, the role of inflammation in the development of atherosclerosis and ACS has been an area of intense study. Proposed causes of inflammation include…
tsmith | February 23, 2010Student guest post by Ron Bedford.
The first week of February 2010 must have been some sort of Post Polio Syndrome (PPS) week. The New York Times ran a story about PPS on February 2nd.
On the following Saturday, during the broadcast of the 2009 AKC/Eukanuba National Championship dog show, a Labrador Retriever named Benton was honored with an AKC Humane Fund Award for Canine Excellence (ACE) in the service category for his work as an assistance dog for his owner, Margo Dietrich, a polio survivor who "lives with physical limitations due to experiencing adult-onset Post Polio Syndrome".
Since…
tsmith | February 22, 2010Student guest post by Anh To.
When I found out my only non-smoking cousin had nasopharyngeal carcinoma (NPC), I was puzzled. With all the hype about cigarette smoking associated with various kinds of cancers in the media, I did not understand why none of my smoking cousins had NPC but the one who didn't smoke did. At first, I thought it must be due to the second hand smoke. Now, I understand that the picture is very complex.
Before I go into what I have learned over the past several months, I need to make a disclaimer. I am not an expert in NPC. I am an average college student. This…
tsmith | May 4, 2009Back to the grind this week unfortunately, but the swine flu/H1N1 story is still developing and still fascinating. The most recent numbers show 286 confirmed US cases in 36 states.
There are many remaining questions on the evolution and epidemiology of this strain--and many pundits sure they know what's going to happen next. Mike takes one of them down--Wendy Orent, who I've blogged about previously. Orent is claiming (based on a black/white version of the evolution of virulence in pathogens) that the spread of this strain is attenuating the virus, and that future outbreaks will be…
tsmith | May 3, 2009Over at DailyKos, DemfromCT has an excellent post explaining why it may be beneficial for schools to close temporarily, even if they only have one confirmed case of swine influenza: H1N1: Why Do Schools Close, And When Do They Open?
DarkSyde also has one up on the basic biology and evolution of the flu.
Nick Kristof discusses our lack of attention to public health and what it means in the event of a pandemic in today's NY Times.
[Updated: and via the comment theads, this post which further discusses what I mentioned here regarding testing--and how the confirmed cases are only the tip…
tsmith | May 1, 2009Nick Anthis has a very nice (and very readable!) overview of why flu viruses (including the new A/H1N1 strain) are resistant to adamantane, one of the antiviral drugs that can be used to treat influenza infections.
tsmith | April 30, 2009I've been seeing a lot of comments mocking the current outbreak of H1N1, and a lot of people (and journalists) who don't understand what "big deal" is about the "snoutbreak" of swine influenza, or don't get what the raising of the World Health Organization's pandemic alert phase up to 5 means. I noted here what the alert level meant, but wanted to discuss it a bit more in a full post; after the jump.
So, some comments I've seen thrown about:
This is all just media hype! Lies about the Mexican cases! The WHO just revised their numbers down to 26 cases and 7 deaths! Why should I believe…
tsmith | April 29, 2009It was only a matter of time:
Iowa Gov. Chet Culver says the state has two probable causes of swine flu.
Speaking Wednesday at a Statehouse news conference, Culver told reporters that officials would know Thursday if the cases are swine flu.
Officials say one case was from a California resident who visited Scott and Clinton counties last week. The other was a woman who returned from Mexico and traveled through Johnson, Des Moines and Muscatine counties.
State Medical Director Patricia Quinlisk says both of the people infected were now recovering.
Should know by tomorrow if they are confirmed…
tsmith | April 29, 2009Brandon Keim at WiredScience has a new article on swine flu genomics.
"This is what we call a reassortment between two currently circulating pig flu viruses," said Andrew Rambaut, a University of Edinburgh viral geneticist. "Why it's emerged in humans is anyone's guess. It hasn't been seen before in pigs as far as I know."
***
"The new neuraminidase gene that came in from Eurasian swine is one we've never before seen circulating in humans," said Rambaut. "That's one of the reasons it's spreading rapidly. Very few people will have any immunity to this particular combination, which is what…
tsmith | April 29, 2009The latest numbers of confirmed cases from the CDC were released about an hour ago. 91 cases have been confirmed, with the largest numbers in New York (51), California (14), and Texas (16). One new case has also been confirmed in Nevada, one in Indiana, one in Arizona, and 2 in Michigan; the other Ohio case I know of is still pending, apparently. Ongoing investigations are also taking place in multiple states, so expect the number to keep rising for the time being. [Update: 2 cases just confirmed in Massachussets, and three in Maine.]
The first fatality has also been reported: a 23-month-…
tsmith | April 28, 2009Back in 2007, I wrote about an outbreak of swine influenza from an Ohio county fair. The peer-reviewed paper analyzing the swine influenza isolated from that outbreak has just recently come out. From the abstract:
The swine isolate, A/SW/OH/511445/2007 (OH07), was evaluated in an experimental challenge and transmission study reported here. Our results indicate that the OH07 virus was pathogenic in pigs, was transmissible among pigs, and failed to cross-react with many swine H1 anti-sera. Naturally exposed pigs shed virus as early as 3 days and as long as 7 days after contact with…
tsmith | April 28, 2009Stories in Spanish: Costa Rica becomes the first Central American country to confirm swine flu ("gripe porcina"). A 21 year old who had traveled to Mexico is in stable condition. An additional 16 cases were examined but were negative. Brazil is also examining 11 travelers; cases are also being examined in Panama, Honduras, Argentina, and Uruguay, and Chile.
In Asia, South Korea is examining a possible case, while China's stepped up its efforts to look for cases (and blocked import of pork from the US and Mexico).
Most of the cases that are being examined have traveled to Mexico…
tsmith | April 27, 2009...asked Joe. Answer: only a few days to sequence, clean up the data, and submit to NCBI. Seven H1N1 swine flu sequences are up (H/T Jonathan Eisen). I've not had a chance to crack anything open yet, but I hope to see some analysis from more of the genomics geeks soon...However, one bummer is that they don't have any from the Mexico cases available--and particularly, any sequence data from any of the fatal cases. These will be helpful to see if there are any point mutations that could possibly account for a virulence difference between the Mexican and US cases. (Unlikely, I'd guess,…
tsmith | April 27, 2009As expected, new potential cases are being investigated in several states, including an additional possible case in Northern California, 2 potential cases in Indiana, a potential case in Ohio and another in Michigan [updated: and some in Massachusetts too]. New York has also confirmed 20 cases now, and 17 more are suspected (check here for additional information--updated as new cases come in and are confirmed or ruled out). Around the world, four in France have apparently tested negative, as have two potential cases in Australia, while 2 in Scotland have been confirmed positive. In Mexico…
tsmith | April 27, 2009For those of you looking to follow new cases (most of them suspected at this point, not confirmed), a great resource is HealthMap. Reports are popping up of possible infections worldwide: Scotland, Spain, Australia, and New Zealand. Certainly additional possible cases will be showing up over the coming days as well.
One thing I've seen mentioned (including here in the comments) is a question about the unlikelihood of a flu outbreak in Mexico in late April. Isn't influenza a cold-weather bug? Well, yes and no. Influenza circulates year-round at a low level, but it lasts longer in the…
tsmith | April 26, 2009According to new information from the CDC, in addition to the 2 cases in Texas, 7 in California, and 2 in Kansas, the 8 in New York have now been confirmed, and an additional case has also been confirmed in Ohio (I've not seen any info on that case)--UPDATED below. Investigations are apparently ongoing in at least 2 Canadian provinces, also (British Columbia and Nova Scotia). An investigation is also ongoing in New Zealand after teenagers took a trip to Mexico and have shown flu-like symptoms.
Concerning to say the least, but crof and revere both have some excellent posts to keep things…
tsmith | April 26, 2009Over the last 24 hours, I've received a few comments and even more emails asking about or discussing the possibility of a "cytokine storm" triggered by the H1N1 swine flu reassortant. Is this what's happening in the cases from Mexico? Discussion after the jump...
Let me begin with a bit of background on what's meant by a "cytokine storm." In response to infection, the body has a number of ways to fight back against the invading microbe. Cytokines are one part of this defense. These are molecules produced by a number of different types of cells in response to infection that act as signals…
tsmith | April 25, 2009Sorry for the radio silence--I've been working on grants and manuscripts like a fiend, and so have tried to limit as many distractions as possible (which, unfortunately, includes blogging). However, the swine flu news is right up my alley, so I do just want to say a few words about it, and point you to some excellent stories already up elsewhere.
First, in case you've not been paying attention to the news in the last few days, there have been 8 reported cases of swine influenza infections in humans (6 in California and 2 in Texas, with additional suspected cases) and reports from Mexico…