Selenium the cause of Lechuza Caracas polo horse deaths

Regular commenter and friend of Terra Sig, leigh (the path forward), let us know overnight that Florida State Veterinarian Dr Thomas J Holt officially confirmed that selenium overdose killed 21 Venezuelian polo horses in Wellington, Florida, on 19 April.

An attempt by an Ocala, Florida, compounding pharmacy to reproduce an equine dietary supplement called Biodyl resulted in a toxic dose of sodium selenite to be given to the horses. The pharmacy is cooperating fully with the FDA and other authorities but there is no official word as to whether the pharmacy made a calculation error or were given an improper formula by the requesting veterinarian.

We predicted that of the components of Biodyl, sodium selenite was the most likely culprit. It is required in microgram doses and even a 100-fold calculation error could have led to toxicity. A superb comment thread developed at our post with several members of the equine community weighing in as well as a discussion on the practice of compounding pharmacy.

For my money, the best news outlet coverage of the toxicology report comes from Andy Reid and Missy Diaz at the South Florida Sun-Sentinel. This report has the most details on the investigation and is the only one I could find this morning that indicates the magnitude of the selenium toxicity:

Toxicology results of the horses showed the animals had as much as 15 times the amount of selenium in their blood and as much as 20 times in their liver as normal, said veterinarian Dr. John Harvey, the executive associate dean of the University of Florida's college of veterinary medicine.

The Sun-Sentinel also has the most complete coverage of other related events including video of a memorial service for the horses, a photo gallery, and references Twitter discussions of the case.

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tags: polo horses, poisoned polo ponies, Florida, International Polo Club Palm Beach, Lechuza Caracas, Franck's Pharmacy Victor Vargas, patron of Venezuelan team Lechuza Caracas (1), left, hits a shot past Carlos Gracida (2), right, of Mokarow Farms in the Stanford U.S. Open Polo Championships at…
Last weekend, 21 Venezuelan polo horses collapsed and died at the US Open championship match at the International Polo Club Palm Beach in Wellington, Florida (AP, CNN). The deaths have now been associated with injection of a veterinary mineral supplement produced by a compounding pharmacy in Ocala…
tags: polo horses, poisoned polo ponies, Florida, International Polo Club Palm Beach, Lechuza Caracas, Franck's Pharmacy, Biodyl, selenium A Lechuza pony stands ready for play. Image: New York Social Diary (2008). The mysterious deaths of twenty-one Venezuelan polo horses was apparently due to…
Today's post comes to your courtesy of yet another of my revered Canadian colleagues: pharmacist Scott Gavura, author of the excellent Science-Based Pharmacy blog. Back in April, 21 Venezuelan polo horses from the Lechuza team died at the U.S. Open Polo Championship in Palm Beach County, Florida…

My labrador died because of congested lungs, the vet said were due to either an allergic reaction to a bacterial infection or paraquat poisoning. Thought I should mention it.
My deepest sympathy goes out to everyone who had anything to do with the ponies who died.

By christina johnson (not verified) on 06 May 2009 #permalink