Medicine

Believe it or not, there was once a time when Dr. Mehmet Oz didn't bother me that much. At least, for all his flirting with woo, I never quite thought that he had completely gone over to the Dark Side. Although I probably knew deep down that I was fooling myself. Maybe it was because Dr. Oz is a surgeon--and not just a surgeon but a cardiac surgeon. After the enthusiastic embrace of pseudoscience by so many surgeons, and in particular Dr. Michael Egnor's embrace of "intelligent design" creationism and mind-brain dualism, maybe I didn't want to believe that yet another surgeon had fallen for a…
Given that I have put myself out of commission due to a musculoskeletal injury I acquired over the weekend, I thought a discussion of joint injuries and such would be most appropriate in my Robaxocet induced state. Just last week Travis discussed the issue of injuries associated with exercise among obese individuals. In that post, based on recent evidence, Travis concluded: "...in overweight and obese individuals, exercise (in the form of walking) has little or no association with injury or illness." However, there still remains the issue of various musculo-skeletal problems which appear to…
Klotho (KL) is an interesting gene. It produces an enzyme which seems to be involved in repressing cellular senescence by regulating the p53 pathway, mouse mutations in these genes produce the symptoms of accelerated aging, and there are even a couple of known human alleles correlated with changes in longevity and coronary artery disease. The current research is at the level of basic science, though, asking how this gene product fits into the regulatory web that maintains cell states; it is not ready for any kind of medical work, I don't even know how we would take advantage of the…
It has now been nearly two months since Andrew Wakefield was forced to resign from Thoughtful House in the wake of his being found guilty of research misconduct by the British General Medical Council (GMC), the withdrawal of Wakefield's infamous 1998 Lancet paper, and the withdrawal of Wakefield's last grab at scientific credibility, his infamous hepatitis B "monkey study." After a period of silence, over the last week, Wakefield has started to pop up in the public eye again, most recently last week in an interview for an independent filmmaker that is getting wide play in the anti-vaccine…
This week Canadian public health researchers published the long awaited paper on possible association between vaccination for seasonal influenza the previous flu season and risk of having a medically diagnosed infection with pandemic influenza during the first wave of infections (April to July) just as that season was ending. When preliminary results were first announced there was only vaccine against seasonal flu, which was still being given, and the results were contrary to what we thought we knew about flu biology and the immune system. Inevitably it became caught up in the wider anti-…
Beware, North Carolina. Beware. Your law has become quack-friendly to the point where doctors can do almost anything. Why, you may reasonably wonder, am I saying this? The answer is what appears to be the end of a long and painful story of cancer quackery and anti-vaccine celebrity that has tainted North Carolina for years now. Do you remember Dr. Rashid Buttar? Regular readers know who he is, as he's been a recurring character on this blog since the very beginning. Most recently, he figured prominently in the case of Desiree Jennings, the young woman who claimed that the flu vaccine caused a…
He's baa-aack. You knew he couldn't stay gone for long, I'm sure. He's just like the zombie who rises again just as the hero turns his back, thinking the zombie dead, or the blond terrorist in Die Hard who appeared to have met his end hanging from a chain only to appear later in the movie, just when it looks as though it's all over and Bruce Willis has triumphed, to try to take a shot at him. That's right. I'm referring to the anti-vaccine quack whose trial lawyer-funded, incompetent, and probably fraudulent research launched a thousand autism quacks looking to "cure" autism "vaccine injury…
About four months ago, the skeptical blogosphere was abuzz about a tragic story. The story was that of a Belgian man named Rom Houben, who had been unfortunate enough to have been in a motor vehicle collision and suffered serious brain injury. That brain injury left him in a comatose state, which had been diagnosed as a persistent vegetative state. What brought him worldwide prominence was a claim by neurologist Steven Laureys that he was not in a persistent vegetative state at all, but was rather fully conscious and "locked in," meaning that he could see, hear, and feel everything but could…
The AMA just took over a journal called Disaster Medicine and Public Health Preparedness. In fact they proudly announced they were the exclusive publisher and distributor of the journal, formerly published by Lippincott, Williams and Wilkins. I wouldn't even know about it except it was in connection with a press release of an article likely to be of interest any health care worker: ":Which Health Care Workers Were Most Affected During the Spring 2009 H1N1 Pandemic?" by Santos, Bristow and Vorenkamp of Weill-Cornell Medical School in New York. And the AMA even said it was redesigning the…
Last month, in response to some truly despicable activities by animal rights zealots, I wrote a series of posts about how animal rights activists target even researchers' children and appear to fetishize violence. This simply continued a string of posts that I've done over the years, the longest (and, in my not-so-humble-opinion, the best) deconstructs a lot of the bad scientific arguments used by animal rights activists to claim that animal research is useless, or nearly so, as well as other arguments made by extremists. One of the key points emphasized in these responses is that, regardless…
I'm here at The Informationist: Collaboration between scientists and librarians to support informatics research at the Embassy Suites in DC. It's sponsored by Elsevier as part of their Research Connect series. (these are stream of consciousness) Tonna - VP North Am, Academic & Gov't. Research productivity metrics more important for funding decisions. Data for institute and gov't research funding decisions. Their goals: increase productivity (doing science & getting grants), provide data for making funding decisions. Increased use of ejournals correlates with increased publication and…
I hate to write about that woo-meister supreme Mike Adams more than one time in a week. For one thing, his website, NaturalNews.com, is a font of pseudoscience and quackery rivaling the infamous Whale.to, which makes it powerfully seductive to go back to that well again and again for blogging material. Although taking on an Adams screed is almost always a lot of fun for me, it's also too easy. Mike's craziness is so strong that, while it almost guarantees an entertaining piece for my blog, going back to that well too often risks making me fat and lazy as a skeptic and potentially boring you.…
Over the next few months, Peter and I will be re-posting some of our favourite posts from our Obesity Panacea archives.  The following article was originally posted on December 2, 2009. Image by Mike Baird. There is a surprising amount of controversy about the ability of physical activity to prevent the development of obesity. Sure, obese individuals tend to perform less physical activity than their lean counterparts, but that doesn't prove causation. And almost every week it seems that there is a news story reporting that the obesity epidemic is caused by diet. Period. If you believe…
It has often been written on this blog and elsewhere that the mark of a true crank is hatred of the scientific consensus, be it consensus regarding the theory of evolution, the science that says homeopathy is impossible, anthropogenic global warming; various areas of science-based medicine; or the safety and efficacy of vaccines. Perhaps the most famous expression of distrust of a scientific consensus is the famous speech by Michael Crichton, in which he famously said: Let's be clear: the work of science has nothing whatever to do with consensus. Consensus is the business of politics. Science…
Every so often, real life intrudes on blogging, preventing the creation of fresh Insolence, at least Insolence of the quality that you've come to expect. This is one of those times. So enjoy this bit of Classic Insolence from back in November 2007 and be assured that I'll be back tomorrow. Remember, if you've been reading less than two and a half years, it's new to you, and, even if you have been reading more than two and a half years, it's fun to see how posts like this have aged. I wish I had thought of this one, but I didn't. However, I never let a little thing like not having thought of…
Continuing with the tradition from last two years, I will occasionally post interviews with some of the participants of the ScienceOnline2010 conference that was held in the Research Triangle Park, NC back in January. See all the interviews in this series here. You can check out previous years' interviews as well: 2008 and 2009. Today, I asked Ivan Oransky from Reuters Health and Embargo Watch to answer a few questions. Welcome to A Blog Around The Clock. Would you, please, tell my readers a little bit more about yourself? Where are you coming from (both geographically and philosophically)?…
Early in the prolonged economic crisis a patient who had lost his factory job came to see me. He no longer had insurance, but he had plenty of health problems. Our office normally doesn't see uninsured patients (we simply can't afford to) but from time to time we make exceptions. I changed his prescriptions to the cheapest possible effective medications and gave him an online resource for the meds that did not have inexpensive alternatives. I referred him to a clinic that has the resources to care for the uninsured and that may be able to help him get his diabetic supplies. By doing this…
    Image Source: Monkeys in the NewsMonkeys In the News has alerted me to an Associated Press story today about a Nevada research lab, part of Charles River Laboratories, that is one of the world's largest suppliers of clinical and laboratory research services to pharmaceutical and biotech companies. The company was fined after thirty monkeys died as the result of not following proper procedures. While it is clear that there are necessary medical reasons for using primates in invasive experiments, I think everyone can agree that strict regulations need to be put in place to prevent…
It's been a while since I wrote about this topic, but I fear for the future of medicine. Regular readers know what I'm talking about. The infiltration of various unscientific, pseudoscientific, and even anti-scientific "complementary and alternative medicine" (CAM) modalities into academic medicine seems increasingly to be endangering science-based medicine. Worse, this infiltration of quackery seems at least as bad, if not worse, in academic medicine, so much so that Dr. R.W. coined a most exquisite term for the increasing prevalence of pseudoscience in medical academia: Quackademic medicine…
The work up of "fever of unknown origin" (FUO) is a classic exercise in internal medicine. Originally defined as a temperature greater than 38.3°C (101°F) on several occasions for more than three weeks with no diagnosis after one week of inpatient study, the definition has shifted. This reflects the dramatic increase in the sophistication of outpatient work ups in the fifty or so years since the term was formally defined. About a third of cases turn out to be infection, another third cancer, a smaller percentage so-called collagen vascular diseases such as lupus. A significant percentage…