New treatments for cancer from elephants?

Check out this new YouTube video describing a new study aimed at discovering how elephants resist developing cancer:

More like this

Soon, an elephant in the chemo room?
I am disappointed that the media pay so much attention to silly proposals at the end of an experimental study or to university press releases aimed at promoting a basic research lab. There are much more realistic approaches taking into account the physiology of the cancer cells, which may lead to treatment, and do not receive such publicity.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799276/

By Daniel Corcos (not verified) on 24 Oct 2015 #permalink

There is a difference between manipulated
mice and animals naturally selected like
elephants. Animal expermentation for
cancer research is important but studies
of natural cancers in animals is also
important. There was also ( may be still there
is to day ) research on sharks which have no
cancers. There are many anti-oncogenes
but it might be that TP53 remains therefore
one of the most attractive for gene therapy
In the future, vectors for gene therapy will I
suppose and I hope.
improve. Would it be then silly to treat people
with a high risk of cancer occurence ( for
instance people having being exposed to
high doses of carcinogenic agents) with
a TP 53 gene therapy ?

By Malvy Claude Paul (not verified) on 08 Nov 2015 #permalink

Malvy Claude Paul
"Would it be then silly to treat people
with a high risk of cancer occurence ( for
instance people having being exposed to
high doses of carcinogenic agents) with
a TP 53 gene therapy ?"
My answer would be: yes it would be silly. Because it is not sure that it would be efficient, because there is a risk of insertional mutagenesis and because gene therapy efficiency is not 100%. This means that cells no efficiently transfected could be led to proliferate as a side effect of gene therapy, and it will counteract the beneficial effect.

By Daniel Corcos (not verified) on 12 Nov 2015 #permalink

When I mean vectors will improve, I
mean that their rate of transfection cell efficiency
will be very high and that they will
have a very high rate of targeted ( non random) insertion
in DNA. Of course the animal models will
be required to test the benefit/risk ratio
before any clinical trial. There is no treatment
without side effects. With actual chemotherapy
it is known that secondary cancers can be
induced by chemotherapy. This does not
prevent of course to use chemotherapy to
treat patients.

By Malvy Claude Paul (not verified) on 14 Nov 2015 #permalink