From medicated powder to cigarettes, it's no secret that small molecule ligands can induce a cold sensation. Usually, this means menthol. However, like any protein ligand, non-natural small molecules can stand in.
Icilin has an enhanced affinity for receptors to which menthol binds:
Icilin induces sensations of intense cold when applied orally in humans, and induces 'wet dog shakes', a behavioral marker of cold sensation, when given to rats.
Icilin: 2.5X more effective than the leading thermosensory agonist at causing wet dog shakes!
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Where do you find all these amazing molecules?
I've been following this blog for some months now, and although not a chemist I find it fascinating the array of molecules humans have synthesized for any conceivable purpose.
How does Icilin compare to Menthol as far as Toxicity? I know menthol is relativly safe, but what about icilin?
http://www.nature.com/news/2007/070528/full/070528-5.html