Cotinine is the principal metabolite of nicotine:
Cotinine spends quite awhile in the body; it can take several days to eliminate, so it's a marker for recent exposure to tobacco (secondhand smoke counts). This makes it one of the few drugs other than marijuana that will reliably show up on a drug test.
- Log in to post comments
More like this
There are a number of tobacco-associated compounds that are formed by reactions of nicotine. Cotinine is a metabolite formed from nicotine in the body - it hangs around a relatively long time, so it is a good marker for recent nicotine exposure.
Additionally, a number of nitrosamines, formed during…
Parents who smoke in front of their children expose them to the toxic chemicals found in passive cigarette smoke, but surely this is only seen in older kids, right?
"Researchers issue new warning on risks of smoking near babies"
Parents who smoke near their newborn babies are turning their children…
Half of us in the US now live in cities, towns or states that ban smoking in public places, including restaurants and bars (it's nice to be more enlightened than Europe in at least a few things):
Seven states and 116 communities enacted tough smoke-free laws last year, bringing the total number to…
Because there can never be enough research to illustrate the positive impact of public health policy on people’s health, here’s another one. This one found that comprehensive smoke-free indoor air laws resulted in a lower risk of asthma symptoms and fewer asthma-related doctor’s visits.
Based on…
Is it an active metabolite?
Given the eldritch solvent powers of N-methylpyrrolidinone, I'm thinking UNKNOWN HAZARDS! and a desperate opportunity for Homeland Severity/EPA/War on Drugs to SAVE OUR CHILDREN! by requiring weekly inventory and reportage of every drop of NMP in academic labs,
http://www.mazepath.com/uncleal/homesec.jpg
Whenever I see a left-handed metabolite I see a commie rat, er, Middle East terrorist. We have always been at war with EastAsia (in the east toward the west, as opposed to Far East Asia that is to the west if you go east enough. Agents of Goldstein!). What good is a police state without police?
How is this metabolite removed from the body? Through the liver or some other route?
Here's a nifty little metabolism pathway graphic, although I suspect it's out of date by now:
http://www.pharmgkb.org/do/serve?objId=PA2011&objCls=Pathway
Actually i have a 3 part question... a) what is the structural type for cotinine? b) how was cotinine discovered? and c) which industry uses cotinine?