Aziridine is kind of neat - like many crazy reactive moieties, it's attracted attention for use in cancer drugs. It's also one of my favorite big strong organiker reagents that finds its way into the biology lab. A cysteine residue in a protein (R-CH2-SH) will react with an aziridine to make R-CH2-S-CH2-CH2-NH3+ (Cf. lysine, which it mimics, R-CH2-CH2-CH2-CH2-NH3+). Never done this reaction, but apparently the superlative nucleophilicity of sulfur is such that the reaction is essentially completely selective.
Cysteine to lysine, just add aziridine!
I would love to hear from anyone who has attempted (succeeded?) at this derivatization.
Cooper blue is one of the most sublime aziridines. It arose from a wash bottle fight in which acetone rather than water was grabbed by accident. Almost any ketone or aldehyde will insert into the azirdine-ammonia brew.
Will chiral leucoforms selectively color given circularly polarized light?
Speaking of crazy reactive moieties, what ever happened to octocubane? It is one of my favorite molecules, from a purely aesthetic standpoint, but there is hardly any information about it on the Internet.