Tetrabutylammonium Fluoride (Getting back to carbon)

Stick that TBDMS on Monday and helplessly flailing around, looking for a way to get your alcohol back? Have a little TBAF:

i-e9c711e796d220efc566142d7a766a3c-tbaf.png

TBAF is one of the most common sources of fluoride ion for silyl deprotection. You usually get a 1M solution in THF with a little water, too. It can be a pain to get rid of when you're not working with big, greasy, drug-like molecules and you're working with water-soluble molecules like RNA.

Tags

More like this

During one of our recent visits to The Tech Museum, we ran across a fun hands-on activity. The pretty purplish circle pictured here is what the younger Free-Ride offspring produced in this activity. The kids thought they were just doing an art project. But there's science in that art. The art…
Over in Scientopia, Janet notes an interesting mis-statement from NPR, where Dina Temple-Raston said of the now-dead terrorist: [O]ne intelligence officials told us that nothing with an electron actually passed close to him, which in a way is one of the ways they actually caught him. As Janet…
"Fluoridation is the single most important commitment a community can make to the oral health of its children and to future generations." -C. Everett Koop Most weekends, I take on a lighter topic, as a way of taking a break from the deep physics, astronomy, and science we share during the week.…
When one thinks of a heroin user, thoughts most often come to mind of a person living in squalor in a big metropolitan city or that of an artsy, poetic hipster (while there are many literary works on the life of heroin users, my all-time favorite is Basketball Diaries, an autobiographical account…