Book & movie reviews

The Hot Zone was first released in 1994, the year I graduated high school. Like many readers, that book and Laurie Garrett's The Coming Plague* really sparked my interest in infectious diseases. In some sense, I have those books to thank (or blame?) for my career. But I'm still going to criticize The Hot Zone, because as a mature infectious disease epidemiologist and a science communicator in the midst of the biggest Ebola outbreak in history, The Hot Zone is now one of the banes of my existence. A recent article noted that the book is back on the bestseller list, going as high as #7 on the…
And now for something a bit different. I've mentioned before that I'm a big fan of zombies. So, I was intrigued when I started seeing press for Warm Bodies, a book by Isaac Marion about a zombie who is, well, not your typical zombie. Recently released as a feature film, I read the book a few weeks ago, and last weekend took my 13-year-old daughter to see the movie. I enjoyed both (as did my daughter), and asked Isaac if he'd be willing to answer a few questions for the blog. His interview is below (a few spoilers, take note): Tara: Your take on zombies is a bit different than most stories.…
Regular readers don't need to be told that I'm a bit obsessed with zoonotic disease. It's what I study, and it's a big part of what I teach. I run a Center devoted to the investigation of emerging diseases, and the vast majority of all emerging diseases are zoonotic. I have an ongoing series of posts collecting my writings on emerging diseases, and far too many papers in electronic or paper format in my office to count. Why the fascination? Zoonotic diseases have been responsible for many of mankind's great plagues--the Black Death, the 1918 "Spanish" flu pandemic, or more recently, HIV/AIDS…
Science denial, I fear, is here to stay. Almost half of Americans believe in creationism. Anti-vaccination sentiment is going strong, despite record pertussis outbreaks. Academics are even leaving their jobs, in part, because of the terrible anti-intellectual attitude in this country. It's depressing and demoralizing--so what does one do about it? Shawn Lawrence Otto's "Fool Me Twice" offers an analysis. Otto's book is good stuff. He devotes the first quarter or so of the book to understanding how we got to where we are regarding science denial and anti-science attitudes. It's a nice…
I rarely write about climate change. As much as it's been hashed out amongst climate scientists, and even many of the former "climate skeptics" have now changed their tune, I readily accept that climate change is happening, and is happening largely due to human activities. More importantly for my field, climate change is also having effects on human health in a number of different ways, from the movement of insect vectors into new areas, to warming of the seas leading to more extreme weather conditions, to the loss of coral reefs and the freshwater that these reefs protect from the…
Malaria is one of mankind's most ancient scourges. A century after the discovery of its cause, various species of the parasite Plasmodium, humanity still remains in its deadly grip in many areas of the world. Malaria is estimated to have caused 225 million illnesses and almost 800,000 deaths in 2009, making it one of the top infectious disease killers. Many of these deaths occurred in children under the age of five. Shah traces the history of malaria from the introduction of the parasite into the human population to modern-day controversies about malaria treatment, research, and funding. It'…
Next to Ebola, my favorite virus would probably be smallpox (Variola virus). I mean, now that it's eradicated in nature, what's not to love about the mysteries it's left us--where it came from, why it was so deadly (or, not so deadly, as in the emergence of the "mild" form, variola minor), and will a new poxvirus emerge to take its place? The topic is particularly germane since the debate still rages on about the fate of the world's smallpox stocks. Smallpox has killed untold millions and influenced the destiny of societies; and as Michael Willrich details in his new book, Pox: An American…
There has been a surge of interest recently in science denial, particularly revolving around the issue of vaccines. Last year saw the release of Michael Specter's Denialism; in the last few months, three others have been released: Seth Mnookin's Panic Virus, Robert Goldberg's Tabloid Medicine, and Paul Offit's "Deadly Choices." More about each of them after the jump. "The Panic Virus" by Seth Mnookin focuses on the general topic of media-fueled science denial, using vaccines as the case study. Like Offit's recent "Autism's False Prophets, Mnookin details a bit of the history of the anti-…
Balance is a tricky thing to find in area, and medicine is notorious for its trade-offs. A drug that may make you well in the long run may also have side effects that make taking the medicine difficult. Even drugs that we often think of as typically innocuous, such as antibiotics, can have an enormous cost associated with their use, both at the individual and the population level. Sachs covers our love-hate relationship with antibiotics and germs in general in her book, Good Germs, Bad Germs. More after the jump... Sachs opens her book with a dramatic example of the cost of our "war"…
I had ended up with a ratty old piece of Army gear, a space suit that belonged to nobody A little voice started speaking in my head. What are you doing here? the voice said. You're in an Ebola lab in a fucking defective space suit. I started to feel giddy. It was an intoxicating rush of fear, a sensation that all I needed to do was relax and let the fear take hold, and I could drift away on waves of panic, screaming for help. Martha was looking into my eyes again. The little voice went on: You're headed for the Slammer. Richard Preston opens his new publication, a collection of essays…
Many of you probably followed the 2005 "Kitzmiller vs. Dover" trial in Dover, Pennsylvania closely. From its early days, with daily updates at the Panda's Thumb to the publication of the ruling--"Kitzmas"-- in late December, the trial was filled with drama and moments right out of the movies. From the defendants' remarkable lying on the stand to Behe's admission that his definition of a scientific theory included astrology, it seemed that each day was better than the last for the pro-science side, culminating in the stinging tongue-lashing doled out by Judge Jones in his decision in favor…
The fever hit suddenly in the form of a piercing headache and painful sensitivity to light, like looking into a white sun. At that point, the patient could still hope that it was not yellow fever, maybe just a headache from the heat. But the pain worsened, crippling movement and burning the skin. The fever rose to 104, maybe 105 degrees, and bones felt as though they had been cracked. The kidneys stopped functioning, poisoning the body. Abdominal cramps began in the final days of illness as the patient vomited black blood brought on by internal hemorrhaging. The victim became a palate…
I asked yesterday what readers considered the most important diseases in history. This was prompted by a new ASM Press book, Twelve Diseases that Changed Our World, written by Irwin Sherman. As I mentioned, Sherman included many diseases readers expected--plague, cholera, tuberculosis, smallpox, syphilis, malaria, influenza, yellow fever, and AIDS. He didn't include a few that popped up repeatedly in the comments--leprosy, measles, and typhoid (or typhus, for that matter). While I think a study of these could have been illuminating (especially leprosy, since much of the stigma…
Regular readers may have seen me mention on occasion my father's rather large family. My dad is the youngest of a family of 13 children--12 of whom survived to adulthood. Before my dad was born, he lost a brother to complications from infection with chicken pox; he had a severe infection and developed a fatal secondary pneumonia at just a year old. This was back in the early 1940s, prior to the widespread use of modern antibiotics and certainly long before vaccination for chicken pox. Still, despite the availability of effective chicken pox vaccines today, people still knowingly…
It's not a rosy picture for girls in math. As Barbie infamously framed it, girls should think that "math is hard." While Mattel (rightly) received a lot of flack for that comment, the sad fact is that Barbie was reflecting the attitude many girls tend to take toward mathematics education: it's difficult, it's boring, and who needs it anyway? Surveys have shown that, while girls and boys in elementary school show similar attitudes toward mathematics, by junior high girls tend to have a negative attitude toward math, along with lower confidence in their ability to handle math problems. Of…
One of the most famous stories in all of epidemiology revolves around the very birth of the science, in the midst of a London cholera outbreak in 1854. At the time, the scientific community was divided over the cause of cholera and other diseases. The majority of them accepted the miasma theory, the idea that disease was due to corrupted air ("all smell is disease," noted sanitation commissioner Edwin Chadwick). This idea dates back to antiquity, and increased in popularity in the Victorian era. It's a great example of something that logically made sense, even though it was wrong.…
Syphilis is a disease frequently shrouded in many levels of mystery. It appeared suddenly in Europe in the late 1400s as a highly virulent and often fatal disease, a disease that could give Ebola a run for its money when it comes to sheer grotesque-ness. Victims may be covered with pustules from head to toe, diseased flesh peeled from their bodies, and patients may be in agonizing pain for weeks or months prior to death. However, after this inauspicious beginning, syphilis seems to have become less virulent, and instead shifted in presentation to more of the chronic disease that we know…
The seventh chapter of Wells' book could be summed up in a single sentence: "biology doesn't need no steeekin' evolution!" Wells argues that, because medicine and agriculture were already doing just fine prior to Darwin's publication of Origin, clearly then, these fields (and others) haven't benefited from an application of evolutionary principles in the time from 1859 to present day, and that Dobzhansky's "nothing in biology makes sense except in the light of evolution" is one big joke. Wells focuses on medicine and agriculture because these are two fields that we all benefit from, and…
Just in time for college graduations comes a new book, "100 Science words every college graduate should know." It's an interesting browse. Others have mentioned it (and Chad even did a pretty nice breakdown of words by discipline); I just thought I'd add my two cents. From the introduction, they note: This book presents 100 words in science that every college graduate, regardless of major or specialization, ought to know. The words were selected because they represent the kind of vocabulary that a person who is literate in science should understand. The words are not the most…
On a recent episode of the drama House, the medical team finds that a patient improves from his illness when he's infected with a particular species of bacteria, Legionella pneumophila. Though mysterious at the time because the cause of the patient's illness was unknown, it was later determined that the patient was infected with naegleria, an amoeba. Legionella is an intracellular bacterium that just happens to naturally live in amoeba. Therefore, when the patient was co-infected with the amoeba and Legionella, the Legionella killed off the amoeba--using one microbe to attack another.…