Drug safety

To get a clearer sense of just how bad our drug overdose problem has gotten, look no further than this year’s County Health Rankings. The annual report found that after years of declining premature deaths, that rate is on the rise and due primarily to overdose deaths. It means we could be seeing the first generation of American kids with shorter life expectancies than their parents. “We often think of the opioid crisis either as happening in very rural communities or as an urban issue,” Kate Konkle, Action Center Team director for County Health Rankings & Roadmaps, told me. “But this is…
By now, the enormity of America’s opioid abuse and overdose epidemic is common knowledge. With 78 Americans dying every day from an opioid overdose and with enough painkillers prescribed to give just about every U.S. adult their own bottle of pills, there’s hardly a community that’s gone untouched by the deadly problem. And a new study reminds us that we’ll be dealing with the aftermath far into the future. The study, published in the form of a “research letter” in JAMA Pediatrics, examined rates of neonatal abstinence syndrome (NAS), a condition that occurs when babies are exposed to drugs…
In 2014, more than 28,000 people in the U.S. died from an opioid overdose. That same year, more Americans died from drug overdoses than during any other year on record, with the escalating numbers fueled by opioid abuse. Solutions to the problem are as complex as the epidemic itself, however a recent study pointed to one tool that can make a significant difference: prescription drug monitoring programs. In a study published this month in Health Affairs, researchers found that implementation of a prescription drug monitoring program was linked to a more than 30 percent reduction in the rate of…
These days, there’s a lot of attention on finding new and creative ways to turn around the nation’s opioid abuse and overdose problem. And it’s attention that’s very much needed because the problem is only getting worse. On the first day of 2016, the Centers for Disease Control and Prevention published new data on prescription drug and opioid overdose deaths, reporting that more people died from drug overdoses in the U.S. in 2014 than during any other year on record. In fact, during 2014, there were about one-and-a-half more drug overdose deaths than deaths from traffic crashes, with most of…
Every day in the U.S., more than 40 people die after overdosing on prescription painkillers. Deaths from a more notorious form of opiates — heroin — increased five-fold between 2001 and 2013. Addressing this problem — one that’s often described as a public health crisis — requires action on many fronts, from preventing abuse in the first place to getting those addicted into treatment. But when it comes to overdoses, there’s one answer we know works: naloxone. Naloxone is a safe prescription medicine that’s highly effective in reversing an otherwise deadly opioid overdose. Typically, emergency…
Last week, the US Food and Drug Administration published a final rule that updates requirements for what prescription-drug information must disclose about potential effects for pregnant and breastfeeding women and their babies. Under the old labeling rules, drugs were placed in one of five categories -- A, B, C, D, or X -- depending on research findings (or lack thereof). An "A" designation meant that human studies did not find adverse effects in pregnant women or their babies, while and "X" designation meant that studies in humans or animals found a risk of problems to the baby and that…
The statistics describing America’s prescription drug abuse epidemic are startling, to say the least. Here are just a few statistics from the Centers for Disease Control and Prevention: In 2009, prescription painkiller abuse was responsible for nearly half a million emergency department visits — a number that doubled in just five years. Of the more than 41,000 drug overdose deaths in the U.S. in 2012, more than half were related to pharmaceuticals. In 2012, U.S. health care providers wrote enough painkiller prescriptions — 259 million — to provide every, single American adult with their own…
“Shift work refers to work that takes place outside of traditional 9-to-5 daytime hours. If you work nights or rotating shifts, you are a shift worker. Many people who work shifts are at risk for developing shift work disorder (SWD) and may experience excessive sleepiness (ES) on the job.” So says the website designed to market the drug known as Nuvigil, sold by Cephalon, a subsidiary of Teva Pharmaceutical Industries, Ltd. Approved by the US Food and Drug Administration (FDA) in 2007 to treat narcolepsy and obstructive sleep apnea and the excessive sleepiness that may come with working a…
The San Jose Mercury News has begun publishing a multi-part series on the alarming use of psychotropic medications among youth in California's foster-care system. Karen de Sá writes: With alarming frequency, foster and health care providers are turning to a risky but convenient remedy to control the behavior of thousands of troubled kids: numbing them with psychiatric drugs that are untested on and often not approved for children. An investigation by this newspaper found that nearly 1 out of every 4 adolescents in California’s foster care system is receiving these drugs — 3 times the rate for…
On NPR's Morning Edition earlier today, Laura Starecheski reported on efforts to use peer groups to prevent young men from becoming rapists. She set the stage by talking with psychologist David Lisack about a study he (and colleague Paul M. Miller of Brown University School of Medicine) conducted among male University of Massachusetts Boston students and published in Violence and Victims in 2002. Knowing that the majority of rapes are never reported to authorities, and wanting to know whether serial rapists were responsible for many of them, Lisack and Brown took a direct approach: They asked…
It looks like a simple piece of paper and it’s nearly as cheap, ideally costing just pennies. But despite its small size, it’s poised to make an enormous impact and potentially save thousands of lives. It’s a new test to spot counterfeit versions of the drug artesunate, which is one of the most important drugs used to treat malaria, a mosquito-borne disease that affects hundreds of millions of people every year. Based on the science of microfluidics, researchers at Oregon State University developed an easy-to-use and inexpensive testing kit that patients and health care providers can use to…
Vaccine safety is one of those topics that has become so tragically mired in misinformation and myth that there can never be enough supporting evidence. So, here’s some more. In a systematic review of the scientific literature on childhood immunizations that will be published in the August issue of Pediatrics, researchers found that vaccine-related adverse events are “extremely rare” and that — once again — the measles/mumps/rubella vaccine (MMR) is not associated with autism. Overall, the study found that while the risks associated with childhood vaccines are not zero, the evidence shows…
Strategies to reduce the deathly toll of prescription drug abuse are reaping positive outcomes, though not every state is taking full advantage, according to a new report from Trust for America's Health. Released earlier this week, "Prescription Drug Abuse: Strategies to Stop the Epidemic" found that 28 states and Washington, D.C., scored six or less out of 10 possible indicators of "promising strategies" to address prescription drug abuse, which has contributed to a startling rise in overdose deaths. Since 1999, such deaths have doubled in 29 states, four of which experienced a quadrupling…
The Supreme Court's decisions on marriage equality and the Voting Rights Act got a lot of media attention last week, but several of the Court's other decisions also have implications for public health -- and they came down on the side of employers, real-estate developers, and drug manufacturers. In a Washington Post op-ed, Georgetown University law professor David Cole warns, "the underlying theme of the Supreme Court’s term was not the recognition of rights, but their dilution." He points to two cases involving employment discrimination: In a pair of less-noticed decisions released the day…
This is a bonus addition to a series exploring the intersections between effectively caring for people living with chronic pain and the rise in unintentional poisoning deaths due to prescription painkillers. To read the three-part series, which explores the science of pain management as well as physicians' and public health workers' roles in preventing opioid abuse and overdose, click here, here and here. by Kim Krisberg "If you really look at how pain affects people and what it means to have pain...you start to view it more as a social phenomenon." These are words from Dr. Daniel Carr, a…
This is the last in a series exploring the intersections between effectively caring for people living with chronic pain and the rise in unintentional poisoning deaths due to prescription painkillers. This week's story looks at the role of public health in curbing the opioid abuse and overdose problem. Read the previous stories in the series here and here. (We'll be publishing a bonus addition to the series next week — a discussion with Dr. Daniel Carr, director of the Pain Research, Education and Policy Program at Tufts University.) by Kim Krisberg A decade ago, only about 10 percent of the…
This is the second in a series exploring the intersections between effectively caring for people living with chronic pain and the rise in unintentional poisoning deaths due to prescription painkillers. (The first post is here.) The series will explore the science and policy of balancing the need for treatment as well as the need to prevent abuse and diversion. This week's story looks at clinical efforts to reduce the risk of opioid abuse and overdose while still caring for patients; the next story will explore the role of public health officials in curbing opioid abuse. by Kim Krisberg Since…
by Kim Krisberg This is the first in a series exploring the intersections between effectively caring for people living with chronic pain and the rise in unintentional poisoning deaths due to prescription painkillers. The series will explore the science and policy of balancing the need for treatment as well as the need to prevent abuse and diversion. This week's story provides a look at the field of pain medicine and the patients it cares for; next week's story will look at the educational and risk reduction approaches physicians are employing to address opioid addiction and overdose. It took…
by Kim Krisberg Researchers studying workers’ compensation claims have found that almost one in 12 injured workers who begin using opioids were still using the prescription drugs three to six months later. It's a trend that, not surprisingly, can lead to addiction, increased disability and more work loss – but few doctors are acting to prevent it, explains a new report from the Massachusetts-based Workers Compensation Research Institute (WCRI). Report researchers looked at longer-term opioid use in 21 states and how often doctors followed recommended treatment guidelines for monitoring…
This post is part of The Pump Handle’s new “Public Health Classics” series exploring some of the classic studies and reports that have shaped the field of public health. Links to past posts in the series are available here. If you have a favorite Public Health Classic to recommend, let us know in the comments. And if you’re interested in contributing a post to the series, email us at thepumphandle@gmail.com (send us a link to the report or study along with a sentence or two about what you find most interesting or important about it). By Dick Clapp Between 1940 and 1971, a synthetic form of…