medicine
oracknows | October 3, 2008You can tell I'm really busy when I fall behind my reading of the scientific literature to the point where I miss an article highly relevant to topics I'm interested in, be they my laboratory research, clinical interests, or just general interests, such as translational research. As you know, I like to think of myself as a translational researcher. Translational research is research that (or so we try to do) spans both basic science and clinical science; i.e., bridges the gap between basic and clinical science. Now don't get me wrong; I don't devalue basic science, and I've said so many times…
oracknows | October 2, 2008After having posted about Jenny McCarthy, my brain hurt so much from the neuron-apoptosing idiocy that she always delivers that I decided I needed to move on to something that wouldn't assault my reason and quite so much. So I headed on over to that uber-repository of quackery and paranoid conspiracy theories, Mike Adam's Natural News.
It's true. Jenny is so dumb that Mike Adams looks intelligent by comparison, and that's saying a lot. Well, not really. In actuality, they're both black holes of negative intelligence, sucking all knowledge and science out of whatever environment self they land…
jstemwedel | October 2, 2008One of the reasons non-scientists see science as at all valuable is that scientific research may result in useful medical treatments. And one of the aspects of science that seems elusive to non-scientists is just how long it can take scientific research to bring those useful medical treatments about.
In the 5 September 2008 issue of Science, Despina G. Contopoulos-Ioannidis, George A. Alexiou, Theodore C. Gouvias, and John P. A. Ioannidis [1] present research that examines just how long it has taken to get from initial discoveries to medical interventions.
Contopoulos-Ioannidis et al.…
oracknows | October 1, 2008I guess that since my resistance failed, and I couldn't resist posting yesterday about the burning stupid that is Jenny McCarthy and her arrogance of ignorance in claiming that vaccines caused her son's autism and her campaigning to "Green Our Vaccines" (in reality, a smokescreen to hide her antivaccinationism), I thought why not go whole hog and get it out of my system? Let's just take in a concentrated dose, as the more Jenny talks the more she discredits the antivaccine movement among anyone with a lick of scientific literacy:
Embedded video from CNN Video
Jenny's on fire with stupid!…
jstemwedel | October 1, 2008
Paul A. Offit, M.D., Autism's False Prophets: Bad Science, Risky Medicine, and the Search for a Cure. Columbia University Press, 2008.
Autism's False Prophets: Bad Science, Risky Medicine, and the Search for a Cure examines the ways that uncertainties about autism's causes have played out in the spheres of medical treatment, liability lawsuits, political hearings, and media coverage. Offit's introduction describes the lay of the land in 1916, as polio epidemics raged. That lay of the land, with public fear and willingness to pursue strange, expensive, and dangerous treatments, evokes a…
oracknows | October 1, 2008...has been posted over at The ScienceBlogs Book Club.
Head on over. As will be the case for all my posts at the Book Club, please leave comments there, not here. Thanks.
oracknows | October 1, 2008Readers may be wondering why I haven't written about Jenny McCarthy's latest brain dead outburst against Amanda Peet. (Actually, brain dead is too kind a description of it, given that Jenny's retort in essence boils down to her having an "angry mob" on her side making Amanda "completely wrong.") It's because I decided to try to resist for once in my life. And I was doing really good at it, too, even though several readers sent me links to various stories about Jenny McCarthy's outburst. Still, I resisted. Even after antivaccinationist financier J. B. Handley wrote a post demanding of Amanda…
oracknows | October 1, 2008Just a quick announcement here:
The ScienceBlogs Book Club is back up and running, and this time the book under discussion is the latest by that Dark Lord of Vaccination himself, that Darth Vader to the antivaccinationist Luke Skywalker, otherwise known as Satan Incarnate to Jenny McCarthy, J.B. Handley, Andrew Wakefield, Dan Olmsted, and the crew of antivaccinationists spreading misinformation and endangering public health and promoting an amazing panoply of quackery to "cure" autism, Dr. Paul Offit. The book under discussion is Autism's False Prophets: Bad Science, Risky Medicine, and the…
oracknows | October 1, 2008When I first started blogging, I liked to refer to myself as a booster of evidence-based medicine (EBM). These days, I'm not nearly as likely to refer to myself this way. It's not because I've become a woo-meister of course. Even a cursory reading of this blog would show that that is most definitely not the case.
So what's changed? Basically, I've come to the realization that EBM is an imperfect tool. Don't get me wrong, EBM goes a long way towards systematizing how we approach clinical data, but there's one huge flaw in it. (I can just see a quack somewhere quote-mining that sentence: "Orac…
sb admin | September 30, 2008If you've spent any time at all reading science and medicine blogs, you know that many of us are quite critical of the way the traditional media covers science. The economics of the business allows for fewer and fewer dedicated science and medical journalists. In the blogosphere, writers have a certain freedom----the freedom not to be paid, which means that the financial fortunes of our medium (the web) are not directly tied to how many readers I bring in with a headline. But all this is just a lot of words introducing my critique of a recent New York Times article.
The article is titled "…
oracknows | September 30, 2008After all the recent blogging about John McCain's health and whether his melanoma will recur or his left ptosis is anything other than from benign causes, probably relating to aging, you just know I couldn't pass this story up:
WASHINGTON (AP) -- If John McCain is elected and goes on to win a second term, there's as much as a one-in-four chance America could see its first woman president -- Sarah Palin.
It's actuarial math.
The odds highly favor either McCain or Barack Obama completing a first term in good health. After that, McCain's odds still are still fairly solid, but his chances of…
clock | September 30, 2008If you came to either the first or the second Science Blogging Conference (or both) you may remember that, among other goodies in your swag bag, you also got a copy or two of Inside Duke Medicine, the employee publication for the Duke University Health System.
And, you may remember it looked kind of....soooo last century ;-)
Furthermore, it had its publishing model backwards - it was Print-to-Web, i.e., the well-crafted articles were first printed in hardcopy and then posted online almost as an after-thought.
Well, that model does not work, so Duke got smart and hired a visionary - Anton…
oracknows | September 30, 2008Yesterday's post was a result of the feeling that I had been getting too snarky for too long a time without doing some serious science or medical blogging. Not that there's anything wrong with being snarky, but a continuous diet of snark eventually gets dull--and not just to readers. However, science blogging is hard. Posts like that take a lot of work (which is why I have a propensity to write such posts over the weekend and post them on Monday). After I do a serious, thoughtful post like that, sometimes I just need a diversion. Sometimes I need to examine something that allows me to deliver…
oracknows | September 29, 2008Ever wonder how it was determined that 98.6° F is the "normal" human body temperature? Ever wonder how that number was determined and how accurate it is?
The Inveterate Persiflager explains.
Not surprisingly, it turns out that "normal" body temperature is more variable and less clear-cut than is commonly thought.
oracknows | September 29, 2008More than two-thirds of breast cancers make the estrogen receptor. What that means is that these tumors have the protein receptor that binds estrogen, which then activates the receptor and causes all the genes that are turned on or off by estrogen to be turned on and off. That's how estrogen acts on normal breast epithelial cells and on breast cancer cells. The significance of this observation is that estrogen receptor-positive (ER+) breast cancers respond to estrogen. Indeed, estrogen contributes to their growth, and blocking estrogen is an effective treatment against them. Indeed, that most…
sb admin | September 27, 2008I'm off to the west coast (of Michigan) for a few days, and if I don't blog, I shall die...or something. So I have a few posts from my old blog to share with you.
Often in the discussion of cult medicines such as homeopathy, acupuncture, and reiki, supporters fall back on "the wisdom of the ancients". This raises a question. Since "the ancients" had it wrong (i.e. their belief systems could not effectively treat disease), were they just stupid?
Any of my historian readers already know the answer, but it's worth going over...
Our forebears were neither more nor less intelligent that we (unless…
oracknows | September 27, 2008I realize I've been a bit remiss in my usual monthly feature, in which I have until recently featured a photo of our blog mascot from the infamous Fleet Pharmaceuticals calendar. This year's been the most bizarre one of all, a radical departure. One might wonder why I've missed August.
Here's why:
That's one scary image of EneMan. However, I do see some utility to it here. I think I may adopt it as the logo for any post in which Orac applies some serious not-so-Respectful Insolence to someone who is so full of crap that he or she requires our mascot's "little friend" to clean it out.…
oracknows | September 26, 2008You know, I'm really, really beginning to like this Dr. Rahul Parikh guy.
Yesterday, he delivered an absolutely delicious smackdown of that chief propagandist for the mercury militia and antivaccine movement, David Kirby. It was at least seven kinds of awesome, and I was truly grateful to Dr. Parikh for doing it so that I didn't have to. This time around, Dr. Parikh's done me another favor. You see, on Wednesday David Kirby gave a talk to Congressional staffers and a few Congressmen. He was also kind enough to include a link to his slides on the Age of Autism blog, and, indeed, such a huge,…
sb admin | September 26, 2008
What is my blood pressure? Is it OK?
Have I been checked for diabetes?
How is my cholesterol? Is that OK?
Am I due for any vaccinations?
Do I need any cancer screening, such as PSA, colonoscopy, mammogram, pap smear?
How is my weight? What is my body mass index (BMI)?
Here is my medication list--does it match yours?
What is my overall cardiac risk? (e.g. see this link).
How do I quit smoking?
ddobbs | September 26, 2008This week's Science is particularly rich in stories, it seems. These stories require a paid subscription, alas -- but the write-ups here, in Science's weekly mailing, make pretty good reading on their own for those without a subscription. My favorites:
From the Minds of Babes
I became fascinated with baby cognition when I did a story on Liz Spelke's work with infants while also raising a couple. Spelke and others have focused on the wee'ns's innate or very early powers of cognition, including numerosity and early logic and perception. Here, though, is an interesting study that proposes…