Horse ERVs are junk too

Arnie got to meet horses for the first time last week :)

It was an unexpected event (horsies were out at a neighbors when we went on a walkie), so I didnt get it on film-- but I can recreate it:


Horses: *SNORT* *unimpressed blink*


Me: Arnie, those horses would kick your ass.  Literally.  Calm yourself.

Horses: *unimpressed blink* *eat grass*

Arnie: Well... maybe Ill just sniff them, then... *sniff*... *gets a little closer* *sniff*... OMG MOMMY THESE ARE MY TWO NEW BEST FRIENDS I DONT EVER WANT TO LEAVE!!!!!! *WAGWAGWAGWAG*

So since Ive written about pig ERVs and cow ERVs and chicken ERVs and dog ERVs-- Why not horse ERVs?

Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing

Brown et al found 978 ERV protein coding genes in the horse genome (there might be more, this is just what they could find with the newest methods).

Of the 978, a grand total of one had the necessary gag, pol, env, and LTRs to even theoretically code for a functional retrovirus.  Like others found earlier in the mouse genome, this particular maybe-virus is inserted 'backwards' relative to the local horse protein coding genes (backwards means there is less of a risk of normal transcription accidentally making retrovirus RNA).

There was one more that had gag, pol, and env, but no LTRs (which I thought was weird).

The rest were a mish-mash of gag, pols, and envs, in various combinations, with or without LTRs.

But I know the question on all of your minds-- How, exactly, do these findings support the Creationist Claim that There Is No Junk DNA, all DNA was specially created by the Christian god 6000 years ago, who sent his only son, Jesus Christ, to Earth to die for our sins?

They dont support the Creationist Claim about ERVs and junk DNA at all, of course.

They looked for expression of 842 of the ERVs.  They found RNA from 79 (not from the more complete ERVs).  About 20 of them were around normal horse genes (again, our genome likes to keep ERVs away from genes).  So, even granting the premise that the ERV transcripts that this group did see werent junk RNA, over 90% of horse ERVs are transcriptionally silent junk DNA. Except the authors know that what they did see was mostly junk RNA:

As very few of the ERV loci identified in this study are capable of producing anything resembling a functional protein clearly their expression is not linked to the production of ERV proteins.

Even in horses, ERVs are junk DNA.  And thats a Good Thing.


More like this

The questions I get asked most often are: How many ERVs are there? How many do we have in common with chimpanzees/gorillas/orangutans/etc? Its hard to answer this.  Depends on what your definition of 'ERV' is.  Because sometimes scientists mean a complete/nearly complete ERV (LTR-gag, pol, env-LTR…
The endogenous retroviruses in your genome are dead. Dead. Junk. They no longer code for functional, infectious viruses. Those viruses are also extinct. They were floating around thousands, millions of years ago, infecting stuff, and now they are hanging out in your genome instead (100% of humans…
So Ive been over the basics of ERVs (Intro, gag, pol, env), but Im still missing a 'basic' aspect of ERVs, even though I talk about them all the friggen time on this blag: LTRs. In exogenous retroviruses, LTRs act as promoters. Genome has all the genes (gag, pol, env), LTRs make sure they, and…
Theyre figuring out what the heck is going on in the saga of ERVs and ALS! 2011: ERVs and ALS 2015: Human endogenous retrovirus-K contributes to motor neuron disease 1-- Of the many ERVs in your genome, the ones they found activated in the brains of people with ALS are HERV-Ks, at two positions:…

But-but-but.... the DEBBIL corrupted those formerly-perfect genes.

It's the DEBBIL I tells ya--- the DEBBIL made them there DNAs.

By Bob Powers (not verified) on 13 Aug 2012 #permalink

When my hound first saw a horse, we were walking in the city, he stopped dead in his tracks, stared at the horse, and a very strange WHOE WHOE WHOE came out of him.

He never made that sound before, or since.

Clearly those now-inactivated ERVs were once functional immortality-related genes that god inactivated after the sinful fall of man. This is why everything now grows old and dies. This proves that Cheezus is real and the earth is 6000 years old. Ramen...I mean Amen!

By Poodle Stomper (not verified) on 15 Aug 2012 #permalink