Drug increases blood flow to brain - implications for stroke?

File:Merino sheep.png Merino sheep. Original: User:Fir0002 Derivative work: Charles Esson at en.wikipedia via Wikimedia Commons

Researchers from Friedrich Schiller University (Jena, Germany) and Heinrich-Heine-University (Düsseldorf, Germany) teamed up to test whether a heart failure medication that is currently being tested might also improve blood flow in the brain. Their findings were published last month in the American Journal of Physiology, Heart and Circulatory Physiology.

According to the study authors, the small blood vessels in the brains of sheep closely resemble those in the human brain. Using imaging techniques, they were able to track blood flow in the brain before and after administration of the vasodilator Serelaxin. Their results showed an impressive 150% increase in blood flow to the cortical brain areas within 15 minutes of administering the drug. The cortex of the brain is the outer gray layer important in our perceptions (vision, taste, hearing, sensations, understanding language, etc - see image below). Additional studies would be needed to determine whether the drug can restore blood flow following a stroke as well as whether the drug is effective at improving cortical blood flow in humans.

Image of cortical regions of the brain by BruceBlaus. "Blausen gallery 2014". Wikiversity Journal of Medicine. DOI:10.15347/wjm/2014.010. ISSN 20018762. - Own work, CC BY 3.0.

Source:

Bischoff S, Schmidt M, Lehmann T, Irintchev A, Schubert H, Jung C, Schwab M, Huber O, Matziolis G, Schiffner R. Increase of cortical cerebral blood flow and further cerebral microcirculatory effects of Serelaxin in a sheep model. American Journal of Physiology Heart and Circulatory Physiology. [Epub ahead of print] 2016 Jul 8. doi: 10.1152/ajpheart.00118.2016.

More like this

The keynote Speaker for the Human Mind and Behaviour theme is Pierre Magistretti of the Brain-Mind Institute at Ecole Polytechnique Federal de Lausanne in Switzerland. Title: Looking Inside Your Brain Abstract: Prof. Magistretti will outline current brain-imaging technology and explore the ethical…
New research from Dr. Scott Boback and colleagues at Dickinson College (Pennsylvania) shows that boa constrictors do not use suffocation as a primary means of killing their victims. Rather, by measuring blood pressure and heart activity of the prey, they were able to determine that the snakes…
It was a day of unexpected findings for the field of cardiology. First, there was the news that patients with stents did not have a longer life span or a reduced number of heart attacks compared to patients treated with statins and other heart drugs. (Only a few years ago, drug-coated stents were…
Lots of good stuff today - hard to pick favourites: Human Preference For Other Species Could Determine Whether They Survive: As humans exert ever-greater influence on the Earth, their preferences will play a substantial role in determining which other species survive. New research shows that, in…

Since starting a new drug to slow my heart my brain is
foggier than usual

By AGNES D POWELL (not verified) on 06 Jul 2017 #permalink

Would a drug used to slow the heart affect the circulation of
blood to the brain

By AGNES D POWELL (not verified) on 06 Jul 2017 #permalink

I'm betting Dr. Dolittle doesn't want to give medical advice online, but you might want to ask Dr. Google about "beta blockers and cognitive impairment".