I've been thinking about other science-type flicks, and for 2nd place I'd like to suggest a couple more:
Gattaca, yes for sure. Wonderful dystopian flick. Absolutely beautiful to watch, a soaring overly melodramatic soundtrack. Crystal clear message about statistical vs individual outcomes, and the power of the human will in a genetically biased world. If you haven't seen it then you need to.
The next nomination, Sleepy Hollow. This is, in my mind, Tim Burton's best flick. Johnny Depp does a wonderful job of taking on the role of bumbling citydwelling Constable Ichabod Crane, sent to rural New York (at least I think it was New York) to solve a mysterious series of murders. The reason I like this movie so much is that Crane employs the scientific method to discover the nature of the supernatural killer and how to put him back in the grave for good. Props to Christopher Walken for being fucking creepy yet again.
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Sleepy Hollow is an actual town in the Hudson Valley (in Westchester County) not that far from NYC.
http://www.hudsonriver.com/rivertowns/sleepyhollow.htm
Thanks, for some reason I had this nagging thought that it might be Philly/Pennsylvania.
I'd nominate Adaptation, starring Nicholas Cage and Meryl Streep.